منابع مشابه
Knee osteoarthritis prevalence, risk factors, pathogenesis and features: Part I
Osteoarthritis (OA) a common disease of aged population and one of the leading causes of disability. Incidence of knee OA is rising by increasing average age of general population. Age, weight, trauma to joint due to repetiting movements in particular squatting and kneeling are common risk factors of knee OA. Several factors including cytokines, leptin, and mechanical forces are pathogenic fact...
متن کاملPathogenesis and epidemiology of osteoarthritis.
Osteoarthritis (OA) is a disease of high prevalence that produces substantial morbidity and is a leading cause of physical and psychological disability and expense, including time lost from work, medical care, and disability support. Until recently, the focus of research into the pathophysiology of OA has been on articular cartilage and has not resulted in either biomarkers of OA activity or ef...
متن کاملOsteoblast role in osteoarthritis pathogenesis
Even if osteoarthritis pathogenesis is still poorly understood, numerous evidences suggest that osteoblasts dysregulation plays a key role in osteoarthritis pathogenesis. An abnormal expression of OPG and RANKL has been described in osteoarthritis osteoblasts, which is responsible for abnormal bone remodeling and decreased mineralization. Alterations in genes expression are involved in dysregul...
متن کاملHypothesis on the Pathogenesis of Osteoarthritis
Osteoarthritic joint changes represent a common phenomenon that, given its progression, is difficult to treat. Accordingly, knowledge about the pathogenesis of osteoarthritis is important. This article compares the mechanism of secondary bone healing with that of osteoarthritis, and can show clear parallels based on numerous study findings. This leads to the hypothesis that osteoarthritis corre...
متن کاملChondrocyte Apoptosis in the Pathogenesis of Osteoarthritis
Apoptosis is a highly-regulated, active process of cell death involved in development, homeostasis and aging. Dysregulation of apoptosis leads to pathological states, such as cancer, developmental anomalies and degenerative diseases. Osteoarthritis (OA), the most common chronic joint disease in the elderly population, is characterized by progressive destruction of articular cartilage, resulting...
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ژورنال
عنوان ژورنال: BMJ
سال: 1970
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.5688.99-b